Machining of Complex Sculptured Surfaces ILO The need for a handbook Jr The need for a handbook on the use of synthetic substrates for assay of proteases of the coagulation and fibrinolytic systems became evident several years ago during the activities of the Subcommittee on Synthetic Substrates of the International Committee on Thrombosis and Haemo stasis (lCTH) The Neural Representation of Experience as Time THATCHER The traditional technology employed in the manufacture of moulds and dies combined conventional milling and electro discharge machining (EDM) but this has been replaced with high speed milling (HSM) which has been applied in roughing serving as a practical resource for all academics