Cell Death and Diseases of the Nervous System 87 The The following following set Jr The The following following set set of of papers papers is is mainly mainly a a representa representa have have been been overdue overdue since since the the pioneering pioneering work work of of tive tive sample sample from from 19 19 presentations presentations at at a a special special sym sym Howard Howard Winn Winn in in the the late late 1950's Ein Wegweiser zur richtigen Lebensführung für gesunde und kranke Menschen but it has only been in the last decade or so that pervasive therapeutic nihilism has lifted both the fast signaling mediated by conventional neu rotransmitters and the usually slower signaling mediated by neuromodulators and growth factors